The National Library of Medicine and the NIH's All of Us Research Program have developed a partnership to build the NNLM All of Us Community Engagement Network (CEN), and to support the training and education platform for the the All of Us Research Program. The CEN focuses on NNLM's mission to improve the public's access to health information, and provide awareness of All of Us to communities that are underrepresented in biomedical research by partnering with libraries across the United States. The CEN offers engagement activities and resources on topics such as health literacy, digital literacy. precision medicine, diversity in biomedical research, and research literacy.

The NNLM All of Us Community Engagement Center (CEC), which coordinates national activities for the NNLM All of Us Community Engagement Network, is located at the University of Iowa Hardin Library for the Health Sciences.